DNA Hemochromatosis Risk Test

easy-to-use mouth swabs

1 in 9 people of European ancestry carry a mutation that can contribute to the overabsoportion of iron which may lead to organ damage.


All-inclusive Price

No hidden lab fees. Free return shipping included.

Fast Results

Get secure results through your private online portal.

Accuracy Guaranteed

All samples are tested twice for absolute accuracy.

Hereditary hemochromatosis stands as the most prevalent genetic disorder in the Western world, take this test to discover your genetic risk.


Characterized by an excessive absorption of iron from the diet, hemochromatosis can lead to the accumulation of iron in organs and tissues, resulting in organ damage and severe health complications.

Although iron begins to accumulate from an early age, symptoms typically manifest later in life. On average, men exhibit symptoms between the ages of 30 and 50, while women are often diagnosed after the age of 50, frequently 10-15 years post-menopause.

When identified early, hemochromatosis is easily manageable through treatment, involving regular blood removal every 2 to 4 months to eliminate excess iron. However, if diagnosis occurs at later stages, after organ damage has occurred, the resulting damages become irreversible.

All-inclusive testing, with no hidden fees

  • All lab fees
  • DNA Collection Kit Supplies and Swabs
  • Free return shipping
  • Certified lab reports
  • 2x testing for accuracy
  • Full customer service & support

What’s inside your kit?

The Hemochromatosis Home DNA Test examines three specific changes in the HFE gene to assess an individual’s susceptibility to developing hemochromatosis.

Hereditary hemochromatosis results from abnormalities in the HFE gene, with the HFE protein’s primary role being the regulation of dietary iron absorption. Mutations in the HFE gene lead to excessive iron absorption, and while this surplus iron cannot be naturally expelled, it can be safely removed through blood donation or phlebotomy. Early detection of hemochromatosis enables regular monitoring of iron levels and scheduled blood removal.

Genes Analyzed

This genetic test identifies three specific mutations in the HFE gene associated with an elevated risk of hemochromatosis:

  • C282Y
  • H63D
  • S65C

C282Y is the most prevalent mutation, linked to the most severe symptoms, while H63D and S65C are additional mutations that can heighten the risk of hemochromatosis. Often, other contributing factors (e.g., hepatitis or alcohol abuse) are necessary for iron overload to occur.

Understanding one’s genetic risk for hemochromatosis can prompt early monitoring and facilitate the initiation of drug treatment to slow down disease progression.

To be at an increased risk of hemochromatosis, one must inherit two faulty copies of the HFE gene. Carriers, possessing one normal and one defective HFE gene, typically remain unaffected.

Note: Although individuals inheriting two defective HFE genes are at an elevated risk of developing hemochromatosis, many may not display any disease symptoms. Additional modifying genes or other factors (e.g., alcohol abuse) are believed to contribute to the risk of hemochromatosis in genetically susceptible individuals.


Diagnosing hemochromatosis based on physical symptoms alone is challenging, as these manifestations overlap with those of various other health conditions. Early symptoms include fatigue and weakness, characteristic “Iron Fist” (knuckle pain), memory problems, depression, shortness of breath, heart flutters, high blood sugar, and low thyroid function.

Be Proactive With Your Health

Understanding your genetic risk provides you with the opportunity for early intervention and prevention through certain lifestyle changes.

Easy sample collection

Each kit contains painless, easy-to-use mouth swabs.

Quality assured

All testing is performed in our ISO 17025, AABB and CLIA certified laboratory.

Live status updates

Track the status of your order and view your results as soon as they are ready.

Private & confidential

Your data belongs to you. We do not share your data with any third party without your permission.

How it works


Order your test kit online or by phone.

Collect & Send

Swab your mouth, then mail your samples to our lab. Free shipping included.

Get Results

Receive confidential results through your secure online portal.


Answers to commonly asked questions about this test.

More Questions »

Hemochromatosis is a condition in which your body absorbs too much iron from the food you ingest. Normal individuals only absorb the amount of iron they need – but with hemochromatosis, extra iron is absorbed and builds up in your organs and tissues, causing damage over time.

This buildup of iron can affect many of your organs, including your liver, heart, and pancreas. It can also result in other health problems like arthritis, diabetes, and skin discoloration.

No. This test can be taken at any time, regardless of whether an individual has recently eaten or not. This test looks for the presence of specific alleles in your DNA, which is not impacted by what you recently ingested. Fasting is not necessary and will not affect the accuracy of results.

Yes, your results are 100% confidential. No one will be able to access your account or your results unless you give them your confidential account login. You can change the password to your account at any time. Please remember to safeguard your login information and not share it with anyone.

DNA testing begins immediately the day that your samples arrive at the laboratory and is completed within 2 to 4 weeks. In some special situations, additional testing may be required, which could increase the turnaround time by a few extra days. You can check the status of your test online 24/7 using your secure account login. Your test report is released immediately once testing is complete.

Once testing is complete, results are released immediately to your secure online portal where you may view, download or share your results with your physician or healthcare provider.

Shopping Cart
Scroll to Top